MKRN3 and puberty

Central precocious puberty (CPP - defined by premature initiation of puberty) is often associated with loss-of-function mutations in the putative RNA binding protein - Makorin Ring Finger Protein 3 (MKRN3). Moreover, hypothalamic MKRN3 mRNA levels decrease before puberty, suggesting its inhibitory role in puberty onset. Although this decrease is well established, the mechanisms that mediate MKRN3 downregulation is unclear. We are using a combination of high throughput sequencing analyses with experimental work to elucidate the mechanisms that regulate MKRN3 expression in the hypothalamus.

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